To observe the alteration of the expression of Cx43 in cerebral astrocyte caused by audiogenic seizure.Method:Genetic epliepsy prone rat P77PMC was used as a model and immunohistochemical method was applied to detect the time-course alteration of Cx43 expression in P77PMC rat‘s cerebral astrocyte.Result :After audiogenic seizure,Cx43 expression was detected in cerebral cortex and hippocampus and appeared time-dependent increasing.Conclusion:Astrocytes in cerbral cortex and hippocampus might be activated by audiogenic seizure which might be beneficial to keep the stability of neuyron‘s peripheral environment and thus protect the neurons.
Background:Peripheral facial nerve paralysis referred to injury of peripheral nerve trunk and its branches due to direct of rindirect force.Physiotherapy could decrease ischemia.Swelling of nerve tissue and degeneration of myelin sheath and axon.Helium neon laser.Semiconductor laser and ultrashort wave were adopted in this group of peripheral nerve paralysis,effect was obvious.Objective:To investigate the effect of acupoint irridiation of three laser in peripheral facial nerve paralysis.Main prognosis index:recovery:all symptoms disappeared,facial expression was free;Obvious effect:five items of main symptoms(frontal grain disappear,Palpebral fissure widened.dysraphism of eyes,disappear of nasolabial groove,angle of mouth crooked) recovered more than three;No effect:no obvious change of mainclinical symptoms and signs.Result:Recovery,25 cases(67%);Obvious effect,11cases (30%);No effect,2 cases(5%) .6cases once treated by simple acupuncture and moxibustion therapy were cured by multiple therapy.Conclusion:Compared with simple therapy,muliple therapy had an obvious effect,with short therapeutic course,and inhibiting relapse at the same time.
Objective:to observe the effects of therapeutic ultrasoud in vitro on hyperlipemia.Methods :Comparing clinical effects of only ultrasound treatment,only administration of Geminifbrozip and combination of these two therapies.Theses patientswere divided into three groups and the follow-up observation was 3 months.Result Curative effect of the ultrasound group was better than that of drug group(P<0.05).Curative effect of the combined therapy group was the best(P<0.01),Result of follow-up suggested that servum glyceryl trioleate and cholesterol replapse rate of ultrasonic group was lower than that of drug goup.Serum glyceryl trioleate and cholesterol relapse rate of combined therapy group was the lowest.Conclusion:Combination of ultrasound treatment in vitro and administration of Geminifbrozip is the best way to treat hyperlipemia,and it is not easy to relapse.
Objective:To observe the effects of electroacupuncture(EA) on plasma levels of endothelin(ET),nitric oxide(NO),and calcitonin gene-related peptide(CGRP) in stress rate,Methods 32 SD rate were randomly divided into 4 groups:control group,stess group,EA after stress and stress after EA group.The plasma levels of NO and CGRP were measured by radioimmunoassay methods the level of NO were measured by biochemical methods.Result:compared with control group,No level of stress group decreased from (22.7±3.8) umol/L to (18.8±5/.2)umol/L(P<0.05),but ET increased from (140±17)ng/L to(177±23)ng/L(P<0.05),compared with stress group,NO level of EA after stress and stress after EA group increased from (18.8±5.2)umol/L to(23.3±4.1)umol/L and (22.9±4.1)umol/L(P<0.05);CGRP level increased from(145±6)ng/L to(184±22)ng/L(P<0.05),but ET level decreased from (177±23)ng/L to (134±8)ng/L,(140±20)ng/L(P<0.05),in which CGRP of stress after EA group has no statistic significance.COnclusion :EA at zusanli point can increase gastric mucosa blood flow and protect gastric mucosa.Its mechanism may be related to the regulation of plasma level of ET,NO and CGRP.
Objective:To investigate etiological and preventive mechanism of AD,and to deliver scientific basis to clinical treatment.Intervention:Methods of grouping,modeling and drug deliver:all the mice were divided into 5 groups randomly:I:control group:Ⅱ:model group:Ⅲ：cerebral convalescence group,Ⅳ:low-dose Rongzhifang group,Ⅴ:large-dose rongzhifang group.There were 12 mice in each group.All the mice received stomach pouring I group with saline,other groups with 0.5g/kg aluminumn chloride to each mouse per day,Ⅲ group with 0.5 g/kg Naofukang additionally,IV and V group with 10,20g/kg Rongzhifang additionally,which lasted 90 days.Main evaluation index:To observe effect of Rongzhifang on learning ability of mice (recording number of correct reaction in 20 times of electric stimulation),hypoxia-endurance ability in ordinary pressure(recording duration from being sealed to death),cerebral and splenic wet weight index,CAT activity and LF content of liver.Conclusion:Rongzhifang can take some effect on prevention and treatment of AD; Amentia caused by aluminum is not irreversible.
目的：评价老年人认知功能下降知情者问卷（informant questionnaire on cognitive decline in the elderly,IQCODE)，面该和电话访问调查痴呆的信度和效度，方法：按照DSM－IV痴呆标准诊断的65例痴呆组患者和67例健康社区老年对照组进行了测查，采用盲法对相关的知情者应用IQCODE的26项版本及16项版本进行了访查，结果：IQCODE面访和电话访问评分的相关系数为0．91，以3．40／3．43为分界值，IQCODE面访的敏感性和特异性分别为89．8％和82．5％，电话访问的敏感性和特异性分别为88．9％和83．6％，16项简短版本的敏感性和特异性分别为86．1％和81．9％，结论：IQCODE是简洁，可靠，有效的痴呆测查工具，面访和电话访问都具有良好的信度，效度和一致性，它与MMSE结合使用，提高了检测的敏感性和特异性。
Objective:to enhance diagnosis and cure rate of somatic disorder,Method :SCL-90,CCMD-3,HAMD,and HAMA were used to evaluate 68 patients suffered from incurable somatic unfitness.Psychotherapy and antidepression therapy were used to treat 53 patients with somatic disorder,After 12 weeks,SCL-90 and clinical evaluation were performed on these patients.Result 53 patients were in line with somatic disorder among 98 with somatic indisposition.Somatic disorder was manifested as disorder of vegetable nerve disorder and persist somatic pain.Clinical symptoms and SCL-90 performance were improved dramatically after psychotherapy and antidepression treatment.Conclusion :Awareness to psychiatric knowledge,training of medical staffs about psychiatric health and appropriate psychotherapy and medicine can improve diagnosis asnd therapy of patients with somatic disorder.
To investigate the effect of rehabilitation therapy on living quality of patients with cerebral hemorrhage in acute phase.Sjbjects:147 cases of cerebral hemorrhage from May 1999 to August 2001 were investigated including 84 males,63 females, aged 38-87(mean:57.4)years old.Main prognosis index and results:According to Brunnstrom a Recovery Statges of Stroke(BRSS),function of limbs was divided into five grades.To patients with grade I to grade Ⅳ，after 1 month of treatment in acute phase,90% improved overI-Ⅱgrades,After a half year of follow-up survey,contracture of joint was observed only in 3% of patients,no disuse atrophy was found.While incases only in 3% of patients,no disuse atrophy was found.While incases not treated in acute phase,only 48% improved over I-Ⅱgrades,and articular contracture appeared in 27% of patient.Seeing from the improvement percentage of living quality,treatment started withid 2 weeks,100% improved,2 weeks-1 month,87%,1 month-3 months,76%,after 3 months ,37%.
Objective :To investigate the interaction and clinical significance of changes in plasma endothelin-1(ET-1) and prostacyclin (PGI2) concentrations in patients with ischemic cerebral infarction.Methods:Plasma ET-1 and 6-keto-PGF1α(resistant metabolite of PGI2) concentrations were measured in 37 pativents(Study group)with ischemic cerebral infarction and 34 healthy volunteers(control group) by radioimmunoassay,Results :Plasma ET-1 concentrations in patients of study group were markedly higher than that of control group(P<0.01) dioimmunoassay,Results:plasma ET-1 concentrations in patients of study group were markedly higher than that of control group(P<0.01) and 6-keto-PGF1α concentrations in patients of study group were significantly lower than that of control subjects(P<0.01),Plasma ET-1 concentrations in control subjects were positively correlated with 6-keto-PGF1α concentrations and no correlation in the study group.COnclusion Both ET-1 and PGI2 are participated in patho-physiologic process of ischemic cerebral infarction.ET-1 is a virulence factor and may play a deleterious role in ischemic cerebral infarction,PGI2 is a conservancy factor and endogenetic antagonist of ET-1,It may provide useful therapy parameter to find out ectogenesis PGI2 or analog for treating the patients with ischemic cerebral infarction with reason.
Objective:to observe the role of community nursing in family rehabilitation of stroke patients with impaired spoken language.Methods:34 patients were divided into 17 pairs according to similar principle.In each pair,patient went into control or rehabilitation group randomly.Patients in control group received nerve drug treatment,while patients in rehabilitation group received spoken language training course as well as nerve drug treatment.The assessment was made after 6 and 12 months of treatment.Results :The capability of language expression and comprehension in training group were significantly improved than in control(P<0,.01) Conclusions Community nursing plays an impotant role in the rehabilitation of stroke patients with impared spoken language.
Hypertension is a serious disease threatening the health of the aged and often leads to disability and even death due to serious diseases of heart,brain and kidney,From 1999,213 cases of senile hypertension were treated in our department.
Large numbers of researches indicate that platelets(PLT) and fibrinogen(FIB) play important roles in the pathogenesis and progress of cerebral thrombosis,In the present study,PLT,platelet mean volume(MPV),platelet aggregation ratio(Pt Agt）and FIB concentration were observed,and the pathogenesis and the progress were discussed.
To compare the curative effect of TIA-caused cerebral infarction and cerebral thrombosis.Intervention:After hospitalization,all cases had anti-platelet aggregation drugs,brain protective agents,and dehydrant according to whether they had intracranial hypertension or not,From the 3 to 7 days after hospitalization,patients had their affected extremity massaged 1 month,There were 2 cases in TIA group died of cerebral hernia and lung infection each on the 3rd and 10th day after hospitalization.There was 1 case in brain thrombus group died of asphyxia on the 8th day after hospitalization.The patients in the two groups had their scores according to score standards of clinical neural function defects on the 1st and 30th day after hospitalization,and the results were treated by statistics.Results:The neural function defcets scores before treatment of TIA group and brain thrombus group were (39.6±3.4) and (36.3±3.0) each.There were no significant difference between the two groups(P>0.05),and the data of the two groups could be compared on statistics,The neural function defects scores after treatment of TIA group and brain thrombus group were(26.4±2.7) and (17.6±1.8) each.The data of TIA group was significantly higher than that of brain thrombus group.There were significant difference between the two groups(P<0.01),This result indicates the neural function defects caused by TIA-caused cerebral infarction were serious than that of brain thrombus.Conclusion:The neural function defects caused by TIA-caused cerbral infarction are more serous than that of brain thrombus.
Objective:To observe the rehabilitation effect after treatment with CTP on acute ischemia cerebral vascular disease(AICVD).Results:Evaluation crieria:effective:NDS score decreased by 50%-80%,survival ability increased to 1-3 degree,including 78 cases in rehabilitation and 24 cases in control group;utility:NDS score decreased by 20%-49%,including 30 cases in rehabilitation and 40 cases in control group;ineffective:NDS scroe increased or decreased by 0%-19%,including 4 cases and 52 cases in control group.The total effective rate of rehabilitation group was 96%,and the rate of control group was 55%.The effect of rehabilitation group was obvious better than control group()P<0.01).COnclusion:For CSF lesion from various causes (ischemia,damage,and infection),CTP should be provided in time in acute period.which can reduce cerebral cell lesion,promote metabolism of nerve cell,improve motor function.Clinical practice also shows the feect of CTP treatment group is better than cytidine diphosphocholine group obviously.
Senile cerbral apoplexy is mainly caused by arteriosclerosis,which is also an important reason to epileptic attack.We analyzed clinical data of 1383 in-patient cerebral infarction cass from 211th Hospital of PLA from January 1996 to October 2001 in which there were 79 secondary epileptic attack of senile arterisclerotic cerebral infarcton.Results were shown followed.
Objective:To investigate impact of early comprehensive rehabilitation treatment on recovery of limbs of patients with post stroke paralysis.Main prognosis indexes:Motion was evaluated using simplified Fugl-Meyer scale,ADL was evaluated using Barthel index.Result:Motion of limbs and ADL showed significant improvement in rehabilitation group,Difference was significant compared with control group(P<0.01).Conclusion:Early comprehensive treatment with facilitation emphasized has significant effect on limbs recovery in poststroke paralysis patients.
Objective:To determine whether a variant(Pl^A2)of the membrane glycoprotein Ⅲa(GP Ⅲa)gene is associated with CAD,Furthermore,the association of the polymorphism with the classical risk factors was analyzed.Methods:Blood was drawn from 105 patients(pt) and 56 controls,some of those undergoing angiography,A 266 base pair fragment of the GP Ⅲa gene was amplified by the polymerase chain reaction(PCR) and digestewd with the MspI restriction enzyme.Genotypes were identified after electrophoresis of digestion products in 2.0% a-garose gel.Results:Of the 105 patients(pt). 65 had acute (n=19) or previous MI,20 had unstable angina (UAP),and 20 had stable angina(SAP) .The Pl^A2 allele was carried by 0% of CAD pt versus 7.7% of Non-CAD control subjects in Uygur population.The Pl^A2 allele was found in 0% of CAD pt versus 0% of Non-CAD control subjects in Han population.Conclusions:the Pl^A2 variant of the gene GP Ⅲa is not associated with CAD in Uygur population and Han population in Urunqi city of Xinjiang Uygur Autonomous Region.
To investigate the effect of health education on type 2 diabetes treatment.Main Prognosis indes:Self-made questinnaire,consisted of name,sex,age,education degree,course of disease,mental state,common problems and need of diabetes knowledge.Result:Before education,88.9% of diabetes patients didn‘t know the common problems,85% could‘t control diet,81% couldn‘t obey medical order,8 cases needing insulin injection get no suitable instruction,3 cases couldn‘t reach expected blood glucose level.All patients expect corresponding educatio.Trough 1 year of follow-up survey after education,95% of the patients got diabetes-related knowledge,100% could control diet,but 30% couldn‘t keep for long time,90% could stick to taking drugs on time and insulin user could grasp right dosage and method.Conclusion:health education to patients with type 2 diabetes can improve their self-protection.help them establish healthy life style,cooperate with doctors and improve their living quality.
Objective :To observe the character and the distribution of dyslipidemia and to explore the relationship between dyslipidemia and the incidence of certain diseases.Method :138 aged cases with dyslipidemia(group A) were observed.Compared with 103 aged cases with normal(group B),and with 126 non-aged cases with dyslipidemia(groupC) to explore the level of lipidemia,the distrbution of all kinds of dyslipidemia and the incidence of certain diseases in three groups.Result:The level of lipidemia in group A was showed that TC,TG and LDL-C were increased,HDL-C was decreased.The proportion of hypertriglydemia was the highest.Conclusion:Hypertriglydemia was closely related to atherosclerosis.
Good environment,amenable climate and clean air are very important for human health.In order to investigate effect of combined convalescent factors in seashore Gulangyu on improving elderly subhealth state.We made a clinical investigation on 92 elders admitted from March 2000 to March 2002,Here is the report.
To investigate effect of diet therapy plus Chinese traditional medicine on gout arthritis in 38 patients.Main prognosis indexes:Cured:All clinical symptoms disapperared.articular activity recoverd,blood uric acid became normal;Effecitve:symptoms were improved,articular activity was flexible,blood uric acid decreased by more than 10%;ineffectives:symptoms and blood uric acid showed no significant improvement.Results:17 cases whowed cure,18 effective prognosis,3 ineffective,total effective rate was 92%.Liver function was normal before and after treament .Articular pain was completely cured in 17 cases,improved in 11 cases,1 cases showed no improvement in joint pain.Conclusion:Diet therapy plus Chinses Traditional Medicine is effective and reliable in the treatment of gout arthritis.
Objective:Researching the individually train for children with autism;Method There were 30 cases with autism who have Been trained individually.There were 26 boys and 4 girls.Ages:26-111 months.the mains were(59.90±22.26) months.All of them onsel the abonrmal within 36 months.The diagnosis criterion was deponed on the ICD-10.The score of ABC were 68-133,the means:(90.87±35.12).The Scores of ABRSC were 37-93.The mains:(59.5±16.20),All cases were inpatients.One senior trainer decided the training scheme for every cases.One teacher trained one cases deponeded on the training scheme.The context included:social skill,speech and language,modify behavior .co-operative moscular movement,skill movement and cognitive train.The training time was 6 hours/per day,The training period were 2-6 months,the mains was 3.5 months,Results: THe social skill have had different progress in 27 cases.There were 13/15 cases could say some words and /or simple sentences after training.There were 12/15 cases have had some converse language etc.There were 13/15 cases could say some works and /or simple sentences after training.THere were 12/15 cases have had some converse language etc.The behavior have modified in 27/30 cases.The score of ABC were 23-97,the means:(57.12±20.39) before discharge,The following up time were 2-32 months after discharge.There were 27 cases get progress continuously.There were 5 cases who can go to the primary school.Conclusion:the individual training for autism are useful.
Lage amounts clinical facts demonstrate that many diseases can induce emotional disturbances and psychological problems such as fear,anxiety,restlessness,agitation and irritability in infantile patients and patients of early age.The author would like to discuss briefly several common psychological and behavioral problesms and the corresponding causes of them.
Objective:To Study the effect of comprehensive rehabilitation for CP.Intervention:325 patients with CP were treated by comprehensive rehabilitation treatmets.The methods included physical therapy,occupational therapy,speech therapy,and Chinese traditional medicaine,Such as massage and scalp acupuncture.Part patients were given orthotherapy and short brace for lower limb.At the same time.psychotherapy and sensory integration therapy were done for the patients with CP.Enlighten education were done for patients with goup.fostered them understanding ability,daily living ability,speech ability through games,music,and handwork.Main prognosis index:The subjects were evaluated by their developmental quotient(DQ) scores including gross motor.fine motor,expressive language,and so on.DQ=[(evepopmental age) /(Chronological age)].100.Remarkable effect:improved DQ are>10 scores:Part Effect:improved DQare≥ 5-9 scores:No effect:improved DQ are ≤4 scores.Result:after 3-6 months treatment,197 cases had remarkable effect,104 cases had part effects,and 24 cases had no effect.The total effective rate was 93.5%.Conclusion:It shows that comprehensive rehabilitation treatments have acquired significant effect for children with cerebral palsy.
Objective:The refractory epilepsy in children is hopeful to be controlled by etiolopgical treatment with the modern diagnosis technology,We have collected 19 cases with refractory epilepsy treated with modern diagnosis technology and performed summary and analysis of the diagnosis as follow.Result:under the help of modern diagnosis technology,the causes of some refractory epilepsy became clear,including 1 pituitary tumor.1 pachygria,2 tuberous sclerosis,1 Yito hypoigmentation,2 local soft focuses after viral encephalitis,1 phenylketonurea.1 third glutaric acidemia,2 ischemia anoxic encephalopathy sequelas,3 infantile spasm,and 5 no-cause lesion.After operation,one patient with pituitary tumor accepted anti-epilepsy drug,and seizure could be controlled.One patient with brain soft lesion got remission by operation treatment,and one with phenylketonurea was advised by low phenylalaine diet combined with anti-epilepsy drugs,whose conditions got remission.The casuses or brain developmental defect,and there was effctive therapy method at present.But clear causes were helpful to diagnosis and evaluate prognosis.Conclusion:It is useful to treat the refractory epilepsy by finding the cause of the disease and eliminating the cause of the disease with the modern diagnosis technology.
Objective:To explore the correlations between effects in schizophrenics treated with clozapine.Method:It was estimated for PANSS at baseline and 28th day as well as for serum clozapine level at 29th day in 66 schizophrenics receiving clozapine monotherapy.Results:(1) There was all statistically significant positive correlations between 6 factors of TESS without coincident items;(2) Of 54 correlations between 6 factirs of TESS and 9 subtracting score rates of PANSS subscales.only 6 arrived statistically significant level;(3) of 23 correlations between 9 subtracting score rates of PANSS subscales without coincident items,only 9 were statistically significant.Conclusion:the same root correlation hypothesis in a narrow sense would be utility in future pharmacology.