目的：探讨失语症早期康复的方法及疗效。方法：将60例失语症患者随机分为早期康复组、延迟康复组、对照组。合理组合语言训练手段进行1个月的治疗。用中国康复中心失语检查法（Chinese rehabilotation research center aphasia examination,CRRCAE)在治疗前后进行评价并进行3组间比较。结果：治疗前3组间CRRCAE评分无显著差异（P＞0．05）。治疗后，早期康复组和延迟康复组与对照组比，均有极显著差异（P＜0．01）。早期康复组与延迟康复组比，有显著差异（P＜0．05）。结论：（1）语言康复训练对失语症患者语言功能的恢复有肯定疗效。（2）早期语言康复较延迟康复，康复效果更明显。（3）合理组合语言训练手段更适合个体化的治疗。
AIM：To explore the prevalence of mild cognitive impairment (MCI) among elderly veterans. METHODS:2 674 veterans (aged 60 years and over) from26 military sanatorium in Shijiazhuang city were evaluated. The Mini-Mental State Examination,Global Deterioration Scale, Activity of Daily Living, Hachinski Ischemic Scale and Hamilton Depression Scale were served as screening tools. RESULTS:The prevalence of total MCI was 8.08% among elderly people. The standardized prevalence of MCI was 6.87% in male and 10.38% in female (P<0.01). The prevalence of MCI tended to increased with aging (P<0.01) and decreased with the elevated degree of education (P<0.05). CONCLUSION:The prevalence of MCI among elderly veterans is lower than that in European and American countries. It should in tensive to monitor the MCI subjects which a high risk Alzheimer disease people. The interventionist treatment for MCI should be turn into the second prevention of the Alzheimer disease.
AIM：To investigate the incidence and related factors of dysphagia in stroke patients. METHODS:Water drinking test were applied to 100 patients who received continuously by neurology and rehabilitation department after their condition was stable. RESULTS:Dyshagia incidence of the 100 cases of stroke patients was 33%.CONCLUSION:Analysis of related factors indicates that incidence of dysphagia has no relationship with sex,age,positipn of the lesion and complications, but shows correlation with status of consciousness,cognitive skill,character of the lesion, position,course,exercise ability, daily life activites. buccofacial apraxia,speech apraxia and aphasia.
AIM：To investigate the effect of transient ischemia attack(TIA) on phospholipid level and the effect of traditional Chinese herb-Yangxueqingnao particles. METHODS:To establish the animal model of TIA in mice by injecting Peroxide through caudal vein, and then feed the mice with Yangxueqingnao particles in different dose. After evoking 4 times of TIA and cut off the head the other day, then measure the level of lysophosphatidic acid (LPA), general phospholipid in blood plasma and brain tissue.RESULTS:Score of the group without treatment was 1.0±0.8, while that of group administered with Yangxueqingnao particles (2g/kg) was 0.5±0.4(P<0.05) LPA level of TIA mice were 6.1±0.4 and 2.1±1.3 and increased significantly compared with that of the control. This changes can be reversed by treatment as can be seen the result 4.9±1.6. general phospholipid level of TIA mice in brain tissue decreased significantly compared with that of the control as the result:(2.3±1.1) and (6.6±2.8)μmol/g, respectively. After treatment, general phopholipid level can reach (4.3±2.0)μmol/g. CONCLUSION:LPA and general phospholipid levels in blood plasma and brain tissue are abnormal in experimental TIA mice, but can be reversed by Yangxueqingnao particles and in can be used in treatment.
AIM：To evaluate the treadmill exercise test on vasovagal syncope and the avoidance steps. METHOD:Examination of treadmill exercise test of 64 adults and analyse of the history, pretest heart rate, the maximum heart rate, metabolic equivalent (MET) and tilt table test. RESULTS:Exercise tolerances in both groups were same with significantly increase of syncope history (43/64,67% in syncope group, while 11/64 or 9% in the controls) and lower basic heart rate of the subjects (74±11 in the syncope group;66±10 in the controls,with P<0.01 statistically) in the syncope group. HUTT positive subjects were significantly more in the syncope group (48/64,75%) than in the controls (2/64), with P<0.01 statistically. CONCLUSION:The exercise syncope was based on the pretest heart rate and previous syncopal history rather than the exercise tolerance in health adults. It suggested an underlying abnormality which may predispose to exercise subjects with vasovagal syncope.
AIM：To study the effect of cerebral ischemia-reperfusion (CI/RP) injury on the function and cycle of T cells in rat. METHODS:Using animal model of brain ischemia-reperfusion injury,H-TdR incorporation and flow cytometer to detect the change of T cell function and cell cycle.RESULTS:After CI/RP, the proliferation ability,Clone formation rate and IL-2 production ability of T cells of experimental group were apparently lower than those of control group (P<0.01), and it more apparent with prolonged ischemia time; with CI/RP the recovery of 3-hour group was more rapid than that of 6-hour group; after CI/RP injury, the proliferation cycle of T cells in each groups changed, the cells in G0/G1 stage were more than those of control group (P<0.01); while the cells in S+G2+M stages were few than those of control group (P<0.01); when CI/RP, amount of cells in G0/G1 stage decrease gradually and that of cells in S+G2+M stages increase gradually.CONCLUSION:after CI/RP, the function of rat spleen T cells decrease and the proliferation and differentiation of cells were inhibited. Early-stage reperfusion can recover damaged immune function as soon as possible.
AMI：To investigate normal value range of low-frequent repeated nerve stimulation (RNS): whether different low-frequent stimulation and different muscles have different normal value rang.METHODS:Low-frequent(3c/s and 5c/s) RNS of 30 healthy people and 27 myasthenia gravis (MG) patients were rest. RESULTS:Superior limit of amplitude of wave attenuation value of low-frequent RNS(x^-±2.5s) of different muscles (orbicularis oculi muscle, deltoid muscle and abductor muscle of little finger) of healthy people was 5.45%-7.55%. According to our normal value standard, RNS positive rate of MG group was 85%; according to the current criteria (amplitude of wave attenuation value>10%), positive rate of MG group was 70%, there was no apparent difference in RNS positive rate (P>0.1). Some labs adopted the criteria that amplitude of wave attenuation value>15%, according to this criteria, positive rate of MG group was 51%. Compared with positive rate (85%) obtained according to our criteria, there was apparent difference(P<0.01).CONCLUSION:Each labs should establish their own normal value standard according to difference muscle and different frequent. If adopt universal standard,amplitude of wave attenuation value 8% or 10% was suggested.
AIM：To investigate mechanism of cassia obtusifolia reducing cholesterol.METHODS:Liver cell of the rate were cultured in vitrol.^14C-cholesterol synthesized in liver cells were measured with Lowry method and scintillation counting apparatus. RESULTS:Extract of cassia obtusifolia can inhibit synthesis of ^14C-cholesterol but Cassiaside B didn′t affect cholesterol synthesis.CONCLUSION:One of the mechanism of cassia obtusifolia reducing blood cholesterol is inhibiting synthesis of cholesterol to some extent, while cassiaside B reducing cholesterol is not by inhibiting synthesis of cholesterol.
AIM：The study evaluated the effects of breathing helium-oxygen (79% heliox and 21% oxygen) on respiratory insufficiency by way of experimental and clinical observations. METHODS:Six mongrel dogs were randomly inspired air or heiox after dripping 2% methacholine in tracheas controlled by 900C ventilator.During the experimental course, respiratory mechanical limits, hemodynamic index and blood gas values were observed. Six ventilated patients with COPD in the respiratory intensive care unit inspired heliox, and the data of respiratory mechanics were recorded. RESULTS:The results demonstrate that heliox can reduced airway resistance, airway pressure,and work of breathing, improve lung effective compliance,but heliox has no side effects on pulmonary circulation and systemic circulation. Heliox improves oxygen diffusion and CO2 climinating. CONCLUSION:Breathing heliox is one of the effective ways for patients with severe obstructive pulmonary diseases.
AIM：To investigate into the changes in bone mineral density (BMD) in patients with Type 2 diabetes mellitus.METHODS:BMD of lumbar vertebrae 2-4 and femur in 63 cases of patients with type 2 diabetes mellitus were measured with dual energy X-ray absorptiometry (DEXA) and were compared with age, sex and BMI-matched normal control group. RESULTS:No significant differences were found in BMD of lumbar vertebrae 2-4 in female of menopause with Type 2 diabetes mellitus(P>0.05), but BMD of total were lower than that of the controls (P<0.05), BMD of neck were significantly lower than that of the controls (P<0.01); No significant differences were found in BMD of L2-4 and femur in male of 50 years old above with Type 2 diabetes mellitus (P>0.05). CONCLUSION:BMD of Type 2 diabetes mellitus is different according to different sex,BMD of female of menopause with type 2 diabetes mellitus were descended easily,especially in areas of neck BMD, it should couse to pay attention to in order to prevent pathologic bone fracture;BMD of male of 50 years old above with Type 2 diabetes mellitus have no the obvious changes than that of the controls.
AIM：The purpose of this study was to examine the association between sleep quality and suicidality in major depressive patients. METHOD:124 patients with CCMD-2-R major depression were assessed with the Pittsburgh sleep quality index (PSQI) and the schedule for affective disorders and schizophrenia (SADS) suicide subscale as well as the Hamilton depression scale (HAMD).RESULTS:Suicidal depressive patients had significantly higher scores of subjective sleep quality,sleep hatency, sleep duration, habitual sleep efficiency and PSQI global scores than nonsuicidal patients. Significant correlations were found between the SADS suicide subscale scores and the measures of PSQI. CONCLUSION:An association exists between poor subjective sleep quality and suicidal behavior in patients with major depression. Serotonergic dysregulation may play a key role in underlying mechanisms of the association.
AIM：To explore the influence of modified electroconvulsive therapy on serum interleukin-6 in schizophrenic patients.METHOD:Testing change of serum IL-6 in 60 cases treated with MECT and 60 control cases treated with clozapine therapy by ELISA method. RESULTS:Serum IL-6 level before treatment of both groups was positive related to SAPS; serum IL-6 level wasn′t related to BPRS total score, factor score and SANS total fractions. IL-6 level of clozapine therapy group decrease apparently after treatment, and IL-6 level was apparently positive related to anxious depressed factor of BPRS; but there was no apparent difference in IL-6 level of MECT group between before and after treatment.CONCLUSION:To schizophrenic patients, clozapine can take effects of immune inhibit through inhibiting serum IL-6; MECT may have different mechanism.
AIM：To discuss the effect of measuring sites to diagnosis of osteoporosis.METHODS: 1087 subjects were measured at both hip and lumbar vertebra sites by DEXA. T4-L4 X-ray were taken and the compressive fracture person were screened. To compare osteoporosis prevalence at different site and determine which site was sensitive to diagnosis of osteoporosis. RESULTS:BMD in both site was gradually decreasing with age increasing.BMD of female was lower than that of male. The prevalence of osteoporosis at hip was higher than that at lumbar vetetra for men and the prevalence of osteoporosis at lumber was higher that that at hip in women. CONCLUSION:BMD at lumbar vetebra as a indicator to diagnosis of osteoporosis is better than BMD at hip for women.
Suicide gene therapy at present is an effective therapy for tumors. The present paper introduces the latest advances of suicide gene therapy in aspects of work introduces the latest advances of suicide gene therapy in aspects of work system, bystander effect, bisuicide gene and suicide gene combining other therapies etc.
AIM:To study the role of the myringotomy and ventilation tube insertion in the hearing rehabilitation of the children with secretory otitis media (SOM). METHODS:Myringotomy and ventilation tube insertions were performed in 56 children with chronic SOM.RESULTS:The pure-tone threshold average (PTA) of six months after operation in 50 cases (91 ears) was improved significantly compared with the preoperative PTA(P<0.01). The effective rate of myringotomy and ventilation tube insertion was 92.3%.CONCLUSION:As a therapeutic method in the hearing rehabilitation of the children with chronic SOM, the myringotomy and ventilation tube insertion should be used as primary surgical therapy.