目的 实验过程中发现神经节苷酯对受损神经有明显的修复作用，探讨临床工作中该药对急性颅脑外伤患者神经功能恢复的影响。方法 将86例急性脑外伤患者随机分为治疗组43例和对照组43例。对照组给予脑外伤的常规治疗(包括必要的手术治疗、脱水消肿治疗和一般的神经营养药治疗等)；治疗组除给予上述的常规治疗外，给予单唾液酸四已糖神经节苷酯注射液(Monosialogangliosides-1,GM-1)40mg加人生理盐水250m1中静脉点滴，1次／d。两组患者均于治疗前和治疗后第2用由专职康复医师进行格拉斯哥昏迷量表(Glascow coma scale,GCS)评定、神经功能缺损(Neural function deficiency,NFD)评定和日常生活活动能力(Baarthalindex,BI)评定。结果 治疗前两组患者的GCS和NFD差异无显著性意义(P>0．01)。治疗2用后，治疗组患者的意识恢复程度、神经功能缺损改善程度和日常生活活动能力均明显高于对照组(P<0．05)。结论 唾液酸四已糖神经节苷酯能更有效地提高急性颅脑损伤患者的清醒度，促进脑外伤患者的神经功能恢复和提高患者的日常生活活动能力。
AIM:To observe the expression of vascular endothelial growth factor(VEGF) and Factor Ⅷ related antigen(FVⅢ-R Ag)in rats brain tissue in the border zone of the bematoma,and explore the relationship between the expression of VEGF and the brain angionesis after intracerebral hmorrhage(ICH).METHODS:Rat of model of ICH was induced by injection of collagenase physiological saline into the right caudate nucleus.The immunohistochemical methods were performed by using different antisera of VEGF and FVⅢ-R Ag in serial sections of rats brain at 12h,1d,3d and 7d after ICH respectively,RESULTS:The amount of VEGF positive cells was markedly in creased.and reached the highest at 7th day in the border zone after ICG(P<0.01),but there were nmo significant difference among the mean value of A of cells at different time points(P>0.05).Compared with the controls,both the FVIII-R Ag positive endothelial cells and the A of cells were significantly different in erperimental ICH goups after 1 day.CONCLUSION:The upregulated expression of VEGF might induce proliferation of endothelial cell and angiogenesis in the border zone after ICH in rats.
AIM:to study the relationship between post-stroke dizziness and psychological factors.METHODS:To choose 82 cases with dizziness after struke.The patients whose medical treatment were invalid were divided into two groups randomly.The experimental group of 43 cases was treated with antipsychotic and the controls group of 39 cases was treated with consolation.RESULTS:The total effective rate in experimental group was significantly higher than that in the control group (P<0.001),CONCLUSION:It is suggested that though the mental scales scores might be normal,post-stroke dizziness should be treated for a long-term helplessly be just a sign of psychological matter,It ought to be discerned and given pertinent treatments.
AIM:Discuss the relationship of pulse pressure and left ventricular function in hypertensive patients.METHODS:We observed the relationship of the pulse pressure and the times of again occurred coronary artery diseases,left vertricular fore and after span,left ventricular back wall thickness and left ventricular ejection fraction(EF) by color Doppler ultrasound in hypertensive patients.RESULTS:The times of again occurred coronary artery diseases,the left ventricular fore and after span and left ventricular EF of each pulse pressure group were significantly difference(P<0.05,P<0.01),CONCLUSION:The pulse pressure may take part in the further impair of left ventricular function coronary artery diseases,COntrol the pulse prssure coronary artery diseases have an important meaning in decreasing the further impair of left ventricular function.
AIM:To investigate the efficacy of huperizine A in treating child language delay and its side effecta.METHODS:37 children with language delay and other developmental diseases from pediatric neurology out-patient department,who did not undergo and language rehabilitation,were treated with huperzine A 50μg bi-daily for more 3 months and then the efficacy and side effects observed.The follow-up was arranged to record the efficacy monthly.RESULTS:37 cases of 40had undergone the whole course and the total efficiency was 68%(25/37).Language developments of other 12 casas were not improved significantly.Other 3 children were not included in because epilepsy were observed among them.CONCLUSION:This pilot trial result suggests that huperzine A has efficacy on child language delay but should be investigated further.Huperzine A may trigger seizure of language delay patients with epilepay.
AIM:To analyze relationship between health quotient and mood stability of 202 cases of Department of Physical Education and 786 cases of public course 2000 in shannxi Normal University,METHODS:Mood stability and healty quotient were surveyed through questionnaire for 202 students of physical department of grade 1998-2001 and 286 of public lessons,RESULTS:Percent of students of physical departmenta with abnormal mood was lower than that of public lessons,more students with high score of mood stability for physical departments compared with public students.CONCLUSION:Quotients index has close relation with mood stability for students of physical department and public lessons.
AIM:To estimate the prognosis of Bell palsy,METHODS:Blink relex (BR),electromyography(EMG),motor latency(ML) and amplitude (AMP) of facial nerve were performed in 42 patients with Bell‘‘‘‘s palsy.The patients were followed about half a year.RESULTS:(1) When 1 of the 3R waves related with the ill side existed or appeared in 3 weeks after onset,97% patients could recover completely.THe recovery time was realted to the time of the occurrence of R wave.(2) When 1 of the 3R waves appeared in the 4th week.60% patients could recover completely,When none of the 3 wasves appeared after the 4th week,100% patients could not recover completely.EMG showed spontaneous activities in 3 of the 6 patients in the 4th week.(3) Motor latency and amplitude of facial nerve were examined when the illness stopped developing.All patients had normal lalencies,5 patinets‘‘‘‘ amplitudes reduced more than 90%.3 of the 5 patients did not appear the related R waves after the 4th week.CONCLUSION:BR might provide the early sign of good prognosis of Bell‘‘‘‘s palsy ,BR together with EMG and ML and AMP of facial nerve might provide the later sign of poor prognosis.
AIM:Abnormal transparent septum is common in clinical works but little in meaning,so some CT reports are not listed.We collected complete abnormal transparent septum cases to perform comparison analysis between CT diagnosis and clinical data.METHODSL:109 abnormal transparent septum diagnosed by CT was compared with symptom of clinics,Axis scanning and no enhanced scanning were used in CT and 2 doctors in charge of sample collection.The 109 cases were excluded with abnormal transparent septum induced by secondary local cerebral strophy and secondary penforation deformity.RESULTS:There were 15 cases with the fifth ventricle of cerebrum and 22 cases with the fifth and sixth ventricle of cerebrums,10 cases with transparent septum cyst,28 cases with translocation of transparent septum,8 cases with no crack in the forebrain,6 cases with poor development of keratoma and 20 cases of other deformity.CONCLUSION:A bnormal transparent septum cannot be omitted and should be clearly diagnosed by CT.
AIM:To evaluate the diagnosis value of MRI for neurovascular compression (NVC) in trigeminal neuralgia(TN) and facial spasm(FS).METHODS:15 patients with TN and 2 patient with F5 underwent SE T1W1 and T2W1 first,then 3D-TOF-SPGR sequences,RESULTS:NVC was found in all the patients,MRI findings were consistent with the surgical operative findings completely,CONCLUSION:It is considered to be of important to use MRI to find out the causes of TN and FS,especially to utilize the 3D-TOF-SPGR sequences,which may possess high sensitivity in determining NVC.
AIM:To observe therapeutic effect of fumigation and steaming with Chinese drugs in the rheumatic diseases.METHODS:Drugs removing rheumatic disease,warming channels and dispersing cold,activating blood circulation were used for fumigation and steaming treatment in 84 cases with rheumatic diseases,once a day,20min each time,10times as a treatment course.Among them,4 cases received treatment for 2 and 3 course of treatment respectively.RESULTS:18 cases were corrected completely,64 were improved,2 showed no improvement,and total effective rate was 98%CONCLUSION:Through hot and therapeutic effect of drugs,lesions can be managed directly in fumigation and steaming trestment.