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  • DISTRIBUTION OF PARVALBUMIN,CALBINDIN-D28 AND CALRETININ IMMUNOREACTIVE NEURONS AND FIBERS IN THE MONKEY BASAL GANGLIA 收费下载
  • Objective To investigate the cellular localization of parvalbumin(PV),calbindin-D28K(CB)and clretinin(CR)in the monkey basal ganglia.Methods Immunocytochemical technique was used to detect PV,CB and CR immunoreactivity in the basal ganglia.Results In the striatum,CB labeled medium-sized spiny projection neuronsshereas PV and CR marked two separate classes of aspiny interneurons,The striatal matrix compartment was markedly enriched with CB while striatal patches displayed a CR-ich neuropil,In the pallidum,virtually all neurons contained PV but none express CB,CR occured only in a small subpopulation of large and small pallidal neurons.In the subthalamic nucleus,there existed a multitude of PV-positive cells and fibers but the number of CR and CB-postive neuronal elements was small,In the substantia nigra/ventral tegmental area complex.CB and CR occured principally in dopaminergic neurons of the dorsal tier of the pars compacta and in those of the ventral tegmental area.PV was strickly confined to the GABAergic neurons of the pars reticular and lateralis.CB-rich fibers abounded in the pars reticular and lateralis,while CR-positive axons were confined to the pars compacta.Conclusion:CB and PV were distributed according to a strikingly complementary pattern in primate basal ganglia,and the use of CB and PV immunocytochemistry may be considered as an excellent tool to define distinct chemoarchitectonic and functional domains within the complex organization of the basal ganglia ,CR was less ubiquitous but occured in small basal ganglia components where it labeled distinct subsets of neurons.Such highly specific patterns of distribution indicate that CB,PV and CR may work in synery within primate basal ganglia.
  • PLASMA SODIUM AND NaCl-SENSITIVE HYPERTENSION 收费下载
  • Objective:To test the following three hypotheses:(1)plasma sodium concentration displays a 24-hour rhythm;(2)the circadian rhythm of plasma sodium is disrupted in SHR fed a basal NaCl diet;(3)high NaCl diet elevates lpasma sodium concentration and may lead to an increase in mean arterial pressure(MAP)of SHR.Methods:After having been instrumented with arterial catheter at 9 weeks of age,all rats(Spontaneously Hypertensive Rat,SHR; Wistar-Kyoto Rat,WKY) experienced two experimental protocols,the mean arterial pressure and heart rate were monitored and the blood samples also been analysed for sodium contents.Results:On basal NaCl diet,plasma sodium concentrations in SHR were significantly higher than those of WKY at almost every time point measured and the plasma sodium concentration and MAP rhythms were in nearly opposite phases;on high NaCl diet,the MAP and plasma sodium rhythms were essentially opposite in WKY,In SHR,the plasma sodium rhythm was inversely related to the MAP rhythm.Conclusion:Plasma sodium displays a significant ciradian rhythm in rats.The high NaCl diet disrupts the normal plasma sodium circadian rhythm only in SHR.
  • GUSTATORY RESPONSES OF NEURONS IN THE PARABRACHIAL NUCLEUS OF RATS 收费下载
  • Objective:To investigate the gustatory neural response of the neurons to five basic taste stimuli in the parabrachial nucleus(PBN),Methods:Evoked responses from PBN taste neurons to tastants were recorded using standard extracellular microelectrode technique.Results:46 taste neurons were recorded in PBN,and most of them were broadly responsive.On the basis of their most effective taste stimuli,these taste neurons were classified into five types.Those are NaCl-,HCl-,quinine-sucrose-,and monosodium glutamate(MSG)-best neurons.Except for the quinine-best neurons,the responses of each best-stimulus category to its best stimulus were significantly stronger than those of others(P<0.01),The results of correlation analysis showed that the correlations between sucrose and each of the other 4 tastants were smaller than those among others.Conclusion:The results suggest that PBN taste neurons probably play an important role in discriminating for hedonic taste.
  • NEGATIVE EFFECTS OF ETHANOL ON ISOLATED GUINEA PIG LEFT ATRIUM AND PAPILLARY MUSCLES 收费下载
  • Objective :To investigate the effects of ethanol on physiological characteristics of the isolated guinea pig left atrium and papillary muscles,Methods:The effects of ethanol on contractility,post-rest potentiation and positive staircase phenomenon were observed in isolated left atrium and papillary muscles of guinea pig.Results:Ethanol(50.0,100.0,200.0mmol.L^-1) prominently inhibited the contraction of papillary muscles.Ethanol(12.5,25.0,50.0,100.0,200.0mmol.L^-1)inhibited the contraction of left atrium,and markedly decreased the post-rest potentiation of myocardial contractility in left atrium.High concentration of ethanol(100,200mmol.L^-1)depressed the positive staircase phenomenon of isolated guinea pig left atrium.Conclusion:These results suggest that ethanol induces inhibitory effects of the contractility,post-rest potentiation,positive staircase phenomenon of letf atrium.The mechanism by which ethanol induces the negative inotropic effects may be related to decrease the amount of calcium released from the intracellular stores.
  • β-IRRADIATION WITH ALIQUID ^188rE-FILLED BALLOON PREVENTS NEOINTIMAL PROLIFERATION IN THE CAROTID OF RABBIT 收费下载
  • Objective:To evaluate the role of β-irradiation with a liquid ^188Re-filled balloon for limiting neointimal proliferation,Methods:Balloon-overstretched injury was performed in the rabbit carotid carotid artery,thenβ-irradiation using the liquid ^188Re-filled balloon was followed immediately,and the prescribed doses was 0,15Gy or 20Gy at 0.5mm from the surface of vessel.All animals survived and were sacrificed at three weeks.Histopathologic analysis was performed.Results In the control group,the neointimal area was larger(0.40±0.04)mm^2,as compared with (0.23±0.06)mm^2 of the 15Gy irradiated group and (0.15±0.02)mm^2 in the 20Gy group(P<0.05),Conclusion:The β-irradiation with a liquid ^188Re-filled balloon is safe and effcetive.
  • A STUDY ON EXPRESSION OF ARmRNA IN HUMEN BPH TISSUE WITH IN SITU RT-PCR 收费下载
  • Objecive:To check and compare the expression levels of human androgen receptor(AR) mRNA in both normal adult prostate(NAP)and benign prostate hyperplasia(BPH) tissues,and to try to find if BPH results from the abnormal transcription of ARmRNA in prostate.Methods:Expression of the human ARmRNA in 14 paraffinembedded prostate tissues(4 cases of NAP and 10 cases of BPH)was studied with the direct in situ reverse transcription-polymerase chain reaction(RT-PCR).Quantitative analysis of the ARmRNA products was performed using the image analysis system.Results:(1)Specific ARmRNA was detected in both NAP and BPH specimens and in both epithelia and interstitial cells,The positive products were relatively densely localized in the cytoplasm of perinuclear zone.(2)The intensity of ARmRNA signals in epithelial cells was significantly stronger than that in interstitial cells(P<0.001).However,there was no statistically significant difference in ARmRNA level between NAP and BPH;(3)The heterogeneity of ARmRNA signal and the androgen-independent cells were observed in prostatic epithelia.Stronger positive signals of ARmRNA were shown in a few basal-cell layer(BCL) cells of BPH tissue,but were not found in that of NAP tissue,Conclusion:Results of this study show that there is no significant difference in the ARmRNA expression between NAP and BPH groups in both epithelium and interstitial cessl,It may indicate that BPH does not result from the ARmRNA transcription in the prostate.
  • GENETIC POLYMORPHISM OF STR LOCI IN CHINESE DRUNGS 收费下载
  • Objective:To study the STR polymorphism in Chinese Drungs.Methods:The genetic distributions of 15 STR loci and Amelogenin locus were generated through coamplification,genescan and genotype from 65 Drungs Results:There were 144 STR and 2 Amelogenin alleles in Drung nationality,with their frequencies ranging from 0.0077 to 0.7846,H0.3723-0.8639,DP0.5567-0.9548,EPP0.2738-0.8358,and PIC 0.3461-0.8456,the accumulative DP 0.9999998and EPP 0.9999894,Conclusion:The study founded a basis for the genetic structure of Chinese ethnic groups ,which is useful for the application to anthropology and forensic science.
  • A STUDY OF ADHESIVE MOLECULE CD44S CD44V VARIANT EXPRESSION IN GASTRIC CARCINOMA WITH RT-PCR 收费下载
  • Objective:To investigate the correlation between transcript CD44s,CD44v and gastric carcinoma invasion metastasis,and to know what role the CD44 gene‘s abnormal activity plays in the genesis and development of gastric cancer.Methose RT-PCR was used to detect mRNA of CD44v and CD44s in 10 gastric normal mucosa,8 gastricprecancerous mucosa,10 tissue adjacent to cancer,40 gastric carcinoma(including metastatic focus) with different pathological features,Result:All gastric carcinomas and non-cancerous tissues expressed CD44s,but CD44v expression rate were0%,12.5%,20%and 72.5%.respectively,in normal gastric mucosa,precancerous tissue,tissue adjacent to cancer,carcinoma,Cancer invasion limited to submucosal layer showed lower CD44v expression rate than invasion extended beyond the muscle layer(P<0.05),Samples with lymph node metastasis showed higher CD44v expression rate than samples without lymph node metastasis,meanwhile,there was significant correlation between metastasis limited to N1 and beyond N1(P<0.05),There was no relationship between CD 44v expression and Lauren‘s type,TNM stage as well(P>0.05),COnclusion:There is a close relation between CD44v and genesis and development of gastric cancer,CD44 gene variant splicing is and early genetic affair in gastric cancer.It Could be a diagnostic tool to screen high0risk people for gastric carcinoma.CD44v can be regard as a parameter in evaluating the potential of cancer cell invasion and metastasis ,as well as prognosis.
  • EXPRESSION OF BAX AND BCL-2 IN MOUSE OFFSPRING BRAIN AFIER MATERNAL ORAL ADMINISTRATION OF MONOSODIUM GLUTAMATE 收费下载
  • Objective:To analyze the excitotoxicity of monosodium glutamate(MSG)in the offspring crebral cortex and hippocampal subresions after maternal oral administration of MSG.Methods:Kunming mice were given per os MSG(4.0g/kg)at 17-21 days of pregnancy and their offspring behaviors were studied at 10,20,30days postnatally.By using inmunohistochemical means,the involvment of Bcl-2 and bax in the glutamate-induced cell death in cortical and hippocampal neurons were examined.Cell damage was assessed by direct cell counting.Results:administration of monosodium glutamate during the fetal period in mice resulted in a moderate increase in the expression of Bax in principal neurons in CA1,CA2,CA3,CA4 and in the cerebral cortex at postpartum 10,20,30 days in the offspring mice,whereas Bcl-2 protein expressions were reduced significantly in the same regions as compared with those of controls.Conclusion:These findings suggest that glutamate toxicity results in cellular death via an apoptotic mechanism in which the Bcl-2/Bax-alpha molecular complex may be involved.The glutamate-induced apoptosis appears to be related to the modulation of Bcl-2 family gene products such as Bcl-2 and Bax.
  • PLASMA EXTRAVASATION IN THE VISCERAL ORGANS CAUSED BY ELECTRICAL STIMULATION OF ACUPOINT “ZUSANLI” IN RATS 收费下载
  • Objective:To investigate the plasma extravasation of visceral organs caused by electrical stimulation of acupoint under the dorsal root reflex and axon reflex conditions.Methods:By the means of measuring the content of Evans blue,this study investigated the plasma extravasation of visceral organs induced by electrical stimulation of acupoint “Zusanli“(ST36).Results:The Evans blue content in the visceral organs such as liver,Spleen,pancreas and the whole gastrointestinal tract in rats increased significantly after electrical stimulation of acupoint“Zusanli“ Compared with that of the control group(P<0.01),The evans blue xetravasstion in the above visceral organs was blocked by pre-treatment of capsaicin(66mmol.L^-1,50μL)into the acupoint.Conclusion:The neurogenic inflammation of the visceral organs evoked by electrical stimulation of acupoint was mediated by the capsaicin-sensitive afferent fibers through the dorsal root reflex and axon reflex.It is a new method to study the correlation of meridian-viscera.
  • VARIATION AND SIGNIFICANCE OF C-MYC PROTEIN IN RAT CARDIAC VOLUME-OVERLOAD HYPERTROPHY 收费下载
  • Objective:To investigate the change of c-myc protein,which was chosen as the response indicator to volume-overloab.Methods:The time and spatial course of c-myc protein expression on the model of rat cardiac volume-overload hypertrophy was examined by immunohistochemical study.Results:The immunohistochemical study indicated the expression of c-myc protein was increased obviously at 4-6 hours(62.73%)than that of control(45.41%,P<0.01) after the volume-overload,then decreased gradually along with development of volume-overload hypertrophy and was decreased extremely at 5 months(r=-0.514,p<0.01),Conclusion:There are disorders in the signal transduction pathways governing the hypertrophic response of cardiomyocytes in hypertrophic myocardium.C-myc gene and the product of it may be only the promoter gene of myocardial hypertrophy.Once switching on,c-myc gene and the product of it do not act anymore;While it may be that c-myc gene and the product of it increased following with myocardial hypertrophy,and have not direct relation to the occurrence and development of myocardial hypertrophy.
  • THE EXPESSION OF ENDOTHELIN-1 IN VENTRICULAR SPETAL DEFECT WITH PULMONARY HYPERTENSION 收费下载
  • Objective:To research the expression of endothelin-1(ET-1)in vascular of lung,endocardium and myocardial vascular of congenital heart disease(CHD) ventricular septal defect(VSD)with pulmonary hypertension (PH),Methods:The streptavidin-peroxidase(SP) immunoassay was used to measure the expression of ET-1 in pulmonary arteriola,pulmonary veinlet,endocardium and endangium of vasa coronary of 20 cases VSD of CHD with PH,and contrast the expression level of these 20 cases VSD of CHD with PH.Results:The expression of ET-1 PH patients in pulmonary arteriola,endocardium,and endangium of vasa coronary was much higher than that of the ontrol group(P<0.05),but there was no significance variance in expression level of pulmonary veinlet between two groups(P>0.05),Conclusion:If VSD of CHD was accompany with PH,the degree of PH has a positive correlation with the amount of ET1 in pulmonary arteriola,ET-1 may be the cause of dynamic PH,and also the acceleration factor of the PH.Howerver,the amount of ET-1 in endocardium and endangium of vasa coronary,may have significant conncetion with the myocardium hypertrophy in dynamic PH.
  • INNERVATION OF SENSORY NERVE TERMINALS IN RAT LUMBAR INTERVERTEBRAL DISC AND POSTERIOR LONGITUDINAL LIGAMENT 收费下载
  • Objective:To investigate the distribution of sensory nerve terminals in the lumbar intervertebral disc and posterior longitudinal ligament(PLL)in an animal model.Methods:Immunohistochemical method was used to visualize nerve terminals with antibodies of substanceP(SP) and calcitonin gene-related peptide(CGRP),and to characterize sensory nerve terminals on sections from lumbar intervertebral disc and posterior longitudinal ligament(PLL) of the sprague Dawley rate.Results :The immunostaining revealed an extensive distribution of SP and CGRP immunoreactive nerve filbers in the surface and most superficial portions of all annulus fibrosus and PLL.Most immunoreactions were observed in ventral and lateral regions of the annulus fibrosus,Morphologically,both thin varicose nerve fibers and tiny punctate nerve terminals could be observed.Conclusion:This study demonstrates an extensive distribution of SP and CGRP immunoreactive nerve fibers throughout the PLL and the peripheral annulus fibrosus and provides an illustration of this distribution.This finding supports a role for the disc as a source of low back pain and provides the neuroanatomic foundation of the disc-genic pain.
  • EXPRESSION OF HEAT SHOCK PROTEIN 90 αIN HEPATOCELLULAR CARCINOMA AND ITS SIGNIFICANCE 收费下载
  • Objective:To elucidate the expression and clinical significance of HSP90αin the tissue of human hepatocellular carcinoma.Methods:Immunohistochemical method was used to detect the expression of HSP90α in human hepatocellular carcinoma tissue Results:The positive expression rates of HSP90α were 10%,52.5%,72.5%in normal liver tissues,adjacent noncancerous liver tissues and hepatocellular carcinoma tissues,respectively.A significantly higher distribution of HSP90α expression in HCC tissues compared with adjacent noncancerous liver tissues and normal liver tissues was observed(P<0.05),HSP90αwas correlated to tumor differentiation and capsule(P<0.05)but not to tumor number(P>0.05),It was also correlated to prognosis of HCC.The mean tumor-free survival period of patients with HSP90α-negative was 38.6 months while that of HSP90α-positive was 25.5 months(P<0.05),Conclusion:HSP90α in overexpressed in human hepatocellular carcinoma and might be used as an indicator to judge the differentiation and prognosis of HCC.
  • THE OVEREXPRESSION AND SIGNIFICANCE OF CYCLIN D1 AND P53 IN CERVICAL SQUAMOUS CELL CARCINOMAS 收费下载
  • Objective:To investigate the significance of overexpresson of eyclin D1 and P53 protein in cervical squamous cell carcinomas.Methods:Fifty cases of invasive cervical squamous cell carcinomas and 10 Cases of normal cervical squamous epithelia were investigated with immunihistochemical technique.Results:The overexpressioin of cyclin D1 and P53 in invasive cervical carcinomas was 70% and 50%,respectively,There was no overexpression of them in the control group.The overexpression of cyclin D1 in grade Ⅱand Ⅲ was much higher than that in grade I(P<0.05),The overexpresson of cyclin D1 in stage Ⅲof cervical carcinoma was significantly higher than that in stage Ⅱ(P<0.05).The overexpression of P53 in grade -Ⅱand gradeⅢ of cervical carcinoma was remarkably higher than that in grade I(P<0.05),Conclusion:The action point of both cyclin D1 and P53 may be at G1/S transtition.The overexpression of them was associated with development and progression of cervical carcinoma probably in different mechanisms and different pathways.
  • A PULSATION-TYPE PORTAL PUMP IN THE TREATMENT OF THE PORTAL HYPERTENTION 收费下载
  • Objective:In order to solve the problem of the decreased protal inflow,decreased metabolic function and dangerous varicosity in portal hypertension,a pulastion-type portal pump was prepared and used in the treatment experiment of canine model for portal hypertension,which was made by thread embolization in the portal vein.Methods:Tow threads which were injected into the two branches of the portal vein would lead to portal hypertension after 2 weeks.A pulsation-type portal pump was made of a si8lica rubber balloon and a T-shaped silica rubber tube.At the 2 tips of the T-shaped tube,two valves allowed the blood to flow in one direction.Two plates on both side of the balloon made the balloon pulsate constantly.One plate made of stainless steel was fixed on one side of the balloon while the other made of a piece of strong magnetic stell were fixed on the other side.The power was supplied by a low frequency alternating magnetic field that was placed outside the adbomen,The T-shaped tip of the pump was then placed into the portal vein at the point above the major collateral branches,The blood pressure and flow of the portal system and the liver metabolic functions were measured .Results:After pump working,the portal blood pressure above the pump increased from (2.969±0.412)kPa to(4.802±0.696)kPa,whereas the portal pressure below the pump decreased from(3.077±0.301)kPa to(1.764±0.421)kPa,and the blood inflow of the liver increased from(0.270±0.028)L.min^-1to(0.396±0.025)L.min^-1.The pressure of the splenic vein decreased from(3.548±0.392)kPa to(2.009±0.333)kPa and the pressure of the gastric fundal vein decreased from(3.459±0.323)kPa to(1.891±0.461)kPa.The ICGK increased from(0.092±0.009)to(0.151±0.013)while the ICGR15 decreased form 19.03±8.50to 9.04±2.50,Conclusion:The pulsation-type portal pump signiicantly increased the blood inflow and the metabolic function of the liver,and decreased the blood p...
  • APOPTOSIS OF HYPERPLASIA AND CANCER OF THE GALLBLADDER WITH CALCULAS 收费下载
  • Objective:To investigate the relation between different extent of proliferation caused by gallstone and gallbladder cancer by counting the proliferation and the apoptosis of the gallbladder cancer for the clinically prevention of the gallbladder carcinoma.Methods:The TUNEL method was used to detect the apoptosis of the specimens and the mean apoptosis indices obtained by quantification of apoptosis cells flurescence by laser scanning confocal microscope were compared among the varible pathological paterns,Results:The mean apoptosis indexed in the mormal and abnormal specimens with cholecystits,simple hyperplasia,low-grade dysplasia,mid-grade dysplasia,high-grade dysplasia and carcinoma were 5.11,5.49,6.32,8.65,12.27,25.24,39.62,119.8,respectively.There was significant difference among the variable pathological patterns and as the lesion progressing,the index went up gradually with the carcinoma had the highest index.Conclusion:the apoptosis indexes increase with the pathological progress during the carcinogenesis of gallbladder cancer caused by lithiasis,which stimulate the epithelium for long time and result in an increasing of the apoptosis;and it may play an important role in the carcinogenesis of gallbladder cancer.
  • EXPERIMENTAL STUDIES ON A NEW TYPE CONCENTRATED ANTICOAGULANT HEMODIALYSATE OF CITRATE IN DOGS 收费下载
  • Objective:To observe the hemodialysis effcet of the new type of concentrated anticoagulant hemodialysate of citrate.Methods:Ten dogs were given intermittent hemodialysis and were divided into 3 groups according to hemodialysis manners.Group 1 was saline-flush hemodialysed with bicarbonate hemodialysate;Group 2 was hemodialysed with citrate hemodialysis without any anticoagulant;Group 3 was hemodialysed with bicarbonate hemodlalysate and heparin,ACT,Ca^2+,BUN,Cr,ALT,AST,TBIL,BDIL,Na^+,Cl^-,HCO3^- and venous pressure were monitored in the animals of each group during hemodialysis.Results:During the hemodialysis in Group 1,venous pressure increased lastingly,resulting in the failure of hemodialysis for 2 hours.Hemodialysis for 2 hours in Group 2 were all finished successfully.ACT was extended and Ca^2+ decreased obviously in the venous end during hemodialysis,And ALT,AST,Ca^2+,K^+,Na^+,Cl^-,HCO3^- after the hemodialysis in Group 2 were not changed(P>0.05).Moreover,the clearance rate of the dialyzers with citrate dialysate increased significantly compared with those of saline-flush and heparin anticoagulation.Conclusion:The anticoagulant and dialytic effects of the new type citrate hemodialysis are satisfactory and better than that of saline-flush.
  • EFFECTS OF THE HYPERTHERMIA AND HARRINGTONINE ON TELOMERASE ACTIVITY OF HL-60 CELLS 收费下载
  • Objective:To understand the mechanism of the hypertherjia and harringtonine in purging of leukemia cells In vitro.telomerase activity of HL-60 cells treated by hyperthermia(42℃ for one hour) and different concentrations of Harringtonine were investigated .Methods Using telomeric Repeats Amplification Protocol(TRAP)and ELISA techniques to analyze the telomerase activity of HL-60 cells,Results:Our results showed that harringtonine inhibited the telomerase activity of HL-60 cells in a dosage related manner,Moreover,the telomerase activity of HL-60 cells was significantly decreased after the hyperthermia treatment as compared with untreated cells.Conclusion:The effect of the hyperthermia and Harringtonine on purging leukemia cellsIn vitro may be mediated by down regulation of telomerase activity of tumor cells.
  • ENDOTHELIAL DYSFUNCTION IN YOUNG NORMOTENSIVE SUBJECTS WITH A FAMILY HISTORY OF ESSENTIAL HYPERTENSION 收费下载
  • Objective:To investigate whether endothelial dysfunction occurred in genetically vulnerable normotensive patients.Methods:Endothelial function was assessed by high-resolution vascular ultrasound.The diameter of brachial arteries were measured at rest.during reactive hyperemia and atfer sublingual nitroglycerine(GTN) in 70 young subjects with a mean age of 44.7(12.1 years:Among them,there were 30 patients with essential hypertension (group 1),20 normotensive patients with a family history of hypertension(group2)and 20 normotensive patients without a family history of cardiovascular diseases that served as controls(group3).Results:Flow-mediated dilatation of brachial arteries was significantly reduced in-roup 1and 2 when compared to group3(Group1:6.8(3.9vs group 2:8.0(3.6vs group3:13.2(5.9%,P<0.01).Conclusion:Endothelium-dependent vasodilatation was impaired in the young normotensive patients with a family history of hypertension.
  • PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ISCHEMIA-REPERFUSION INJURY IN ART KIDNEYS 收费下载
  • Objective:To investigate the protective effects of Ligustrazine on ischemia-reperfusion injury in rat kidneys.Methods Influence of Ligustrazine for injection on the changes of plasma superoxide dismutase(SOD),malondialdehypde(MDA)and endothelin-1(ET-1) as well as the morphology of injured tubule was observed after ischemia-reperfusion injury of rat kidneys.Results:In ligustrazine group,the levels of plasma SOD were significantly higher,but the levels of plasma MDA and ET-1 and the pathological grading of injured renal tubule were significantly lower than those in control group(P<0.05).Conclusion Ligustrazine has a protective effect on rat kidneys with ischemia-reperfusion injury.
  • DISTRIBUTION OF PARVALBUMIN,CALBINDIN-D28 AND CALRETININ IMMUNOREACTIVE NEURONS AND FIBERS IN THE MONKEY BASAL GANGLIA
    PLASMA SODIUM AND NaCl-SENSITIVE HYPERTENSION
    GUSTATORY RESPONSES OF NEURONS IN THE PARABRACHIAL NUCLEUS OF RATS
    NEGATIVE EFFECTS OF ETHANOL ON ISOLATED GUINEA PIG LEFT ATRIUM AND PAPILLARY MUSCLES
    β-IRRADIATION WITH ALIQUID ^188rE-FILLED BALLOON PREVENTS NEOINTIMAL PROLIFERATION IN THE CAROTID OF RABBIT
    A STUDY ON EXPRESSION OF ARmRNA IN HUMEN BPH TISSUE WITH IN SITU RT-PCR
    GENETIC POLYMORPHISM OF STR LOCI IN CHINESE DRUNGS
    A STUDY OF ADHESIVE MOLECULE CD44S CD44V VARIANT EXPRESSION IN GASTRIC CARCINOMA WITH RT-PCR
    EXPRESSION OF BAX AND BCL-2 IN MOUSE OFFSPRING BRAIN AFIER MATERNAL ORAL ADMINISTRATION OF MONOSODIUM GLUTAMATE
    PLASMA EXTRAVASATION IN THE VISCERAL ORGANS CAUSED BY ELECTRICAL STIMULATION OF ACUPOINT “ZUSANLI” IN RATS
    VARIATION AND SIGNIFICANCE OF C-MYC PROTEIN IN RAT CARDIAC VOLUME-OVERLOAD HYPERTROPHY
    THE EXPESSION OF ENDOTHELIN-1 IN VENTRICULAR SPETAL DEFECT WITH PULMONARY HYPERTENSION
    INNERVATION OF SENSORY NERVE TERMINALS IN RAT LUMBAR INTERVERTEBRAL DISC AND POSTERIOR LONGITUDINAL LIGAMENT
    EXPRESSION OF HEAT SHOCK PROTEIN 90 αIN HEPATOCELLULAR CARCINOMA AND ITS SIGNIFICANCE
    THE OVEREXPRESSION AND SIGNIFICANCE OF CYCLIN D1 AND P53 IN CERVICAL SQUAMOUS CELL CARCINOMAS
    A PULSATION-TYPE PORTAL PUMP IN THE TREATMENT OF THE PORTAL HYPERTENTION
    APOPTOSIS OF HYPERPLASIA AND CANCER OF THE GALLBLADDER WITH CALCULAS
    EXPERIMENTAL STUDIES ON A NEW TYPE CONCENTRATED ANTICOAGULANT HEMODIALYSATE OF CITRATE IN DOGS
    EFFECTS OF THE HYPERTHERMIA AND HARRINGTONINE ON TELOMERASE ACTIVITY OF HL-60 CELLS
    ENDOTHELIAL DYSFUNCTION IN YOUNG NORMOTENSIVE SUBJECTS WITH A FAMILY HISTORY OF ESSENTIAL HYPERTENSION
    PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ISCHEMIA-REPERFUSION INJURY IN ART KIDNEYS
    《西安医科大学学报:英文版》封面
      2002年
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