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  • Restrictive Cardiomyopathy Resulting from a Troponin IType 3 Mutation in a Chinese Family 免费阅读 下载全文
  • 目的将在一个中国家庭识别为限制心肌症(RCM ) 负责的病原的变体。方法下一代定序被用于检测变化,结果由定序验证了。我们使用了限制酶消化当变化被识别时,没有任何心脏的继承疾病,在家庭成员和 200 个无关的正常题目测试变化。结果五个个人从心脏病,其中二受不了突然的心脏的死亡死了。二个个人受不了长期的心脏的混乱。变化分析在 exon 揭示了一个新奇错误感觉变化我打的 7 troponin 3 (TNNI3 ) ,在氨基酸位置 150 点与脯氨酸(P) 导致丝氨酸(S) 的替换,哪个有在家庭的疾病的 cosegregated,它被预言可能用 PolyPhen-2 正在损坏。变化没在我们测试了的 200 个无关的题目被检测。我们与 RCM 在一个中国家庭发现了 TNNI3 的一个新奇变化的定序的结论使用下一代,很最近被显示出在识别稀罕孟德尔的混乱的新奇原因的变化成功,。
  • Association Between Geranylgeranyl Pyrophosphate Synthase Gene Polymorphisms and Bone Phenotypes and Response to Alendronate Treatment in Chinese Osteoporotic Women 免费阅读 下载全文
  • Objective To investigate the relationship between geranylgeranyl pyrophosphate synthase(GGPPS)gene polymorphisms and bone response to alendronate in Chinese osteoporotic women.Methods A total of 639 postmenopausal women with osteoporosis or osteopenia were included and randomly received treatment of low dose(70 mg per two weeks) or standard dose(70 mg weekly) of alendronate for one year.The six tag single nucleotide polymorphisms of GGPPS gene were identified.Bone mineral density(BMD),serum cross-linked C-telopeptide of type I collagen(β-CTX),and total alkaline phosphatase(ALP) were measured before and after treatment.GGPPS gene polymorphisms and the changes of BMD and bone turnover markers after treatment were analyzed.Results rsl092SS03 polymorphism of GGPPS gene was correlated to serum β-CTX levels at baseline,and patients with TT genotype had significantly higher serum β-CTX level than those with TC or CC genotype(all P<0.0S).No correlation was found between polymorphisms of GGPPS gene and serum total ALP levels,as well as BMD at baseline.After 12 months of treatment,lumbar spine and hip BMD increased and serum bone turnover markers decreased significantly(P<0.01),and without obvious differences between the low dose and standard dose groups(all P>0.05).However,GGPPS gene polymorphisms were uncorrelated to percentage changes of BMD,serum total ALP,and P-CTX levels(all P>0.05).Conclusion GGPPS gene polymorphisms are correlated to osteoclasts activity,but all tag single nucleotide polymorphisms of GGPPS gene have no influence on the skeletal response to alendronate treatment.
  • Positive Rate of Different Hepatitis B Virus Serological Markers in Peking Union Medical College Hospital, a General Tertiary Hospital in Beijing 免费阅读 下载全文
  • Objectives To investigate the positive rate of different hepatitis B virus(HBV) serological markers,and the demographic factors related to HBV infection.Methods We enrolled all patients tested for HBV serological markers,such as HBV surface antigen(HBsAg),HBV surface antibody(HBsAb),hepatitis B e antigen(HBeAg),hepatitis B e antibody(HBeAb),HBV core antibody(HBcAb),and HBV-DNA from July 2008 to July 2009 in Peking Union Medical College Hospital.The positive rate of each HBV serological marker was calculated according to gender,age,and department,respectively.The positive rates of HBV-DNA among patients with positive HBsAg were also analyzed.Results Among 27 409 samples included,2681(9.8%) were HBsAg positive.When patients were divided into 9 age groups,the age-specific positive rate of HBsAg was 1.2%,9.6%,12.3%,10.9%,10.3%,9.7%,8.0%,S.8%,and 4.3%,respectively.The positive rate of HBsAg in non-surgical department,surgical department,and health examination center was 16.2%,5.8%> and 4.7%,respectively.The positive rate of HBsAg of males(13.3%) was higher than that of females(7.3%,P=0.000).Among the 2681 HBsAg(+)patients,1230(45.9%) had HBV-DNA test,of whom 564(45.9%) were positive.Patients with HBsAg(+),HBeAg(+),and HBcAg(+) result usually had high positive rate of HBV-DNA results(71.8%,P=0.000).Conclusions Among this group of patients in our hospital,the positive rate of HBsAg was relatively high.Age group of 20-29,males,and patients in non-surgical departments were factors associated with high positive rate of HBsAg.
  • Establish Albumin-creatinine Ratio Reference Value of Adults in the Rural Area of Hebei Province 免费阅读 下载全文
  • Objective To establish albumin-creatinine ratio(ACR) reference value of the rural population in Hebei province.Methods This study enrolled 5154 participants.By excluding subjects with hypertension,diabetes,dyslipidemia,cardiovascular and cerebrovascular diseases,kidney diseases,and overweight condition,as well as those with an estimated glomerular filtration rate(eGFR)<60 ml/(min·1.73 m~2),apparently healthy subjects(1168) were selected.Urine albumin was measured by using the immunoturbidimetic method,serum creatinine was measured by using Jaffe’s kinetic method on a morning spot-urine sample,and ACR was calculated.The 95 th percentile of ACR in the healthy subjects was used as the normal upper limit.Results The normal upper limit of ACR was 28.71 mg/g(3.25 mg/mmol) for males and 31.85mg/g(3.60 mg/mmol) for females.Based on this ACR reference value,the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%.Conclusion The ACR reference value in the rural of Hebei province is higher than that of the Western population.
  • Percutaneous Removal of Benign Breast Lesions with an Ultrasound-guided Vacuum-assisted System: Influence Factors in the Hematoma Formation 免费阅读 下载全文
  • Objective To explore the influence factors in hematoma formation after removing benign breast lesions with an ultrasound-guided vacuum-assisted system.Methods A total of 232 females with 312 benign breast masses received excisional biopsy with ultrasoundguided vacuum-assisted system.The pathology of patients,results of hematoma development and outcome,influence factors for hematoma occurrence(nodule size,nodule location,number of nodule,breast shape,menstrual period,efficacy time of bandage,and application of hemostatic agents during the procedure) were recorded.Results Pathologic examination revealed fibroadenomas in 138 lesions,fibroadenosis in 127 lesions,intraductal papillomas in 39 lesions,inflammatory change in 4 lesions,retention cyst of the breast in 3 lesions,and benign phyllodes tumor in 1 lesion.Thirty hematomas were observed in patients(9.6%).Finally,97.0%hematomas were absorbed completely within 6 months follow-up.The incidence rates of hematoma were increased by 24.7%,10.0%,63.2%,13.9%in the nodule diameter larger or equal to 25 mm group,removal of larger or equal to two nodules once time from one patient group,menstrual period group,and larger and loose breast group,respectively(all P<0.05).However,the incidences were decreased by 60.6%in the bandage performed for 12-24 hours or beyond 24 hours group(P<0.05).The multiple logistic regression models revealed that nodule size(x~2=15.227,P<0.001),number of nodule(x~2=7.767,P=0.005),menstrual period(x~2=24.530,P<0.001),and breast shape(x~2=9.559,P=0.002) were independent risk factors associated with hematoma occurrence,but efficacy time of bandage was a protective factor associated with hematoma occurrence.Conclusion The occurrence of hematoma after the minimally invasive operation was associated with nodule size,number of nodule,menstrual period,breast shape,and efficacy time of bandage.
  • Respiratory and Cardiac Characteristics of ICU Patients Aged 90 Years and Older: A Report of 12 Cases 免费阅读 下载全文
  • 目的将调查老特别护理单位(ICU ) 病人的呼吸、心脏的特征。12 个高级 ICU 病人变老的方法 90 岁以上在这研究被注册。我们回顾地收集了所有病人通过医药记录评论的临床的数据。基本人口分布,为承认的主要原因,呼吸、循环的支持的条件,以及预后被记录。吃惊病人和肺病病人明确地以临床的表明,实验室变量, echocardiography,和肺超声结果被分析。结果包括的病人的吝啬的年龄是有男优势的 95 年(8 ~ 4, 66.7%) 。关于为承认的原因, 6 (50.0%) 病人们有呼吸失败, 1 (8.3%) 病人有吃惊,当时 5 (41.7%) 病人们有呼吸失败和吃惊。受不了吃惊的 6 个病人,仅仅, 1 与分发的吃惊被诊断, 5 与心脏性的吃惊。5 个心脏性的吃惊病人, 1 与急性冠的症候群被诊断。剩余的 4 个心脏性的吃惊病人与 Takotsubo 心肌症被诊断。有圣片断举起的病人心肌的梗塞在 24 个小时以内死了。4 个 Takotsubo 病人, 1 在 day-6 上死了,在心功能在 1 ~ 2 个星期内恢复了以后,另外的 3 个病人被转移防止。10 个肺病病人,当社区获得了肺病, 3 被诊断,并且 7 作为医院获得了肺病。仅仅 3 个病人成功地从通风机被断奶。其它要求了与心失败复杂的长期的通风,主要与心脏舒张的心失败。有心脏舒张的机能障碍的 6 个病人的肺超声在自发的呼吸试用期间显示出双边的 B 线。在吃惊的结论老病人趋于开发 Takotsubo 心肌症。心脏舒张的心机能障碍可能是到在老病人的从通风机的困难的断奶的一个主要贡献者。床边肺 ultrasonography 和 echocardiography 能帮助更精确地并且有效地决定呼吸失败和吃惊的实际原因。
  • Life-threatening Spontaneous Retroperitoneal Haemorrhage: Role of Multidetector CT-angiography for the Emergency Management 免费阅读 下载全文
  • ObjectiveTo 评估 multidetector 的角色为威胁生活的自发的 retroperitoneal 的管理的计算 tomography-angiography (MDCTA ) 所有 SRH 病人的医药记录的回顾的分析从 2005 年 1 月 1 日承认了到我们的医院到 2014 年 11 月 31 日的出血(SRH ).MethodsA 被执行。SRH 被定义为无关到侵略过程,外科,损伤,腹的肿瘤或大动脉的动脉瘤。威胁生活的 SRH 与低血压被定义为血液动力学的不稳定性。十六个盒子相遇了包括标准。病人特征,临床的演讲, MDCTA 的成像,治疗形式,病态,和后续数据是 16 个病人的 analyzed.ResultsThe 组包括了 11 个男人和 5 个女人,与 51.5 ±16.4 年的吝啬的年龄。所有病人经历了 MDCTA 扫描考试,并且活跃对比媒介(厘米) 溢出在 9 个病人被发现。Angiography 在 CM 溢出组为 8 个病人被执行。流血容器在经历了成功的 embolization 的 7 个病人被发现。在 CM 溢出组的一个病人没经历 angiography 并且死于流血。没有活跃厘米溢出的七个病人经历了保守管理。流血为所有这 7 个病人被控制,并且 1 个病人死于多重机关失败。从 SRH 熬过的十四个病人成功地被解除。一个病人在 follow-up.ConclusionMDCTA 期间死于心失败在 SRH 的诊断是有用的并且证明了为保守治疗和早干预的结果预兆。
  • Therapy and Prevention of Postoperative Urosepsis of Ureter Endoscopic Lithotripsy for "Non-infection" 免费阅读 下载全文
  • Objective To analyze the risk factors causing postoperative urosepsis in ureter endoscopic lithotripsy without infection preoperatively,in order to make a more effective and safer preventive and therapeutic strategy.Methods From January 2010 to January 2015,5 ureteral calculus patients undergoing ureter endoscopic lithotripsy with holmium laser were retrospectively enrolled in this clinical study.These patients suffered urosepsis postoperatively confirmed by the clinical presentations and laboratory results,while they had no infection in their blood and urine preoperatively.Without delay,5 patients were treated by anti-inflammation and anti-shock.Results The vasopressor drug was stopped gradually after 12-36 hours.The body temperature was recovered to normal in 2 or 3 days,and the blood and urine test results were not abnormal in 7 days.At last,5patients were all cured.Conclusions Stone and operation themselves are potential factors to cause urosepsis after ureter endoscopic lithotripsy.Especially for patients who had not presented infection preoperatively,careful preparation preoperatively,corrective manipulation,low pressure irrigation,drainage and controlling time during operation,and early diagnosis,appropriate treatment postoperatively are the key to cure and prevent urosepsis.
  • Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report 免费阅读 下载全文
  • <正>PAPILLARY thyroid carcinoma(PTC)is the most common thyroid cancer and consists of nearly80%of all cases of thyroid cancer.~1 It is associated with the lowest level of malignancy and an excellent prognosis.Primary thyroid lymphoma(PTL)is a lymphomatous process which develops in the thyroid
  • Treatment of Breast Cancer Accompanied by POEMS Syndrome: A Case Report 免费阅读 下载全文
  • <正>POLYNEUROPATHY,organomegaly,endocrinopathy,monoclonal gammopathy,and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome characterized by the presence of a monoclonal plasma cell disorder,peripheral neuropathy,organomegaly,endocrinopathy,monoclonal gammopathy,
  • Roles of Long-chain Acyl Coenzyme A Synthetase in Absorption and Transport of Fatty Acid 免费阅读 下载全文
  • Long-chain acyl coenzyme A synthetase(ACSL) is a member of the synthetase family encoded by a multigene family;it plays an important role in the absorption and transport of fatty acid.Here we review the roles of ACSL in the regulating absorption and transport of fatty acid,as well as the connection between ACSL and some metabolic diseases.
  • Effect of Autophagy Over Liver Diseases 免费阅读 下载全文
  • In recent years,increasingly evidences show that autophagy plays an important role in the pathogenesis and development of liver diseases,and the relationship between them has increasingly become a focus of concern.Autophagy refers to the process through which the impaired organelles,misfolded protein,and intruding microorganisms is degraded by lysosomcs to maintain stability inside cells.This article states the effect of autophagy on liver diseases(hepatic fibrosis,fattv liver,viral hepatitis,and liver cancer),which aims to provide a new direction for the treatment of liver diseases.
  • Restrictive Cardiomyopathy Resulting from a Troponin IType 3 Mutation in a Chinese Family(Yan-ping Ruan;Chao-xia Lu;Xiao-yi Zhao;Rui-juan Liang;Hui Lian;Michael Routledge;Wei Wu;Xue Zhang;Zhong-jie Fan)
    Association Between Geranylgeranyl Pyrophosphate Synthase Gene Polymorphisms and Bone Phenotypes and Response to Alendronate Treatment in Chinese Osteoporotic Women(Lan-wen Han;Dou-dou Ma;Xiao-jie Xu;Fang Lu;Yi Liu;Wei-bo Xia;Yan Jiang;Ou Wang;Xiao-ping Xing;Mei Li)
    Positive Rate of Different Hepatitis B Virus Serological Markers in Peking Union Medical College Hospital, a General Tertiary Hospital in Beijing(Yue-qiu Zhang;Sai-nan Bian;Xiao-qing Liu[1,2];Shao-xia Xu;Li-fan Zhang[1,2];Bao-tong Zhou;Wei-hong Zhang;Yao Zhang;Ying-chun Xu;Guo-hua Deng)
    Establish Albumin-creatinine Ratio Reference Value of Adults in the Rural Area of Hebei Province(Qiao-jing Liang;Wen Huang;Guo-juan Zhang;Ning-li Wang)
    Percutaneous Removal of Benign Breast Lesions with an Ultrasound-guided Vacuum-assisted System: Influence Factors in the Hematoma Formation(Hui-ping Huo;Wen-bo Wan;Zhi-li Wang;Hong-fei Li;Jun-lai Li)
    Respiratory and Cardiac Characteristics of ICU Patients Aged 90 Years and Older: A Report of 12 Cases(Hong-min Zhang;Da-wei Liu;Xiao-ting Wang;Yun Long;Quan-hui Yang)
    Life-threatening Spontaneous Retroperitoneal Haemorrhage: Role of Multidetector CT-angiography for the Emergency Management(Zhi-wei Wang;Hua-dan Xue;Xiao-guang Li;Jie Pan;Xiao-bo Zhang;Zheng-yu Jin)
    Therapy and Prevention of Postoperative Urosepsis of Ureter Endoscopic Lithotripsy for "Non-infection"(Jun Shen[1,2];Fa Sun;Fang-min Chen;Zhi-ping Wu;Sheng-wen Li[1,3])
    Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report(Qiong Wu;Yu-xin Jiang;Jun-chao Guo;Yu Xiao;Xiao Yang;Rui-na Zhao;Xing-jian Lai;Shen-ling Zhu;Xiao-yan Zhang;Bo Zhang)
    Treatment of Breast Cancer Accompanied by POEMS Syndrome: A Case Report(Jian-yu Dong;Yan Yan;Min-feng Liu;Zhao-ze Guo;Jing-yun Guo;Chang-sheng Ye)
    Roles of Long-chain Acyl Coenzyme A Synthetase in Absorption and Transport of Fatty Acid(Fan Gao;Xue-feng Yang;Nian Fu;Yang Hu;Yan Ouyang;Kai Qing)
    Effect of Autophagy Over Liver Diseases(Dong-qian Yi;Xue-feng Yang;Duan-fang Liao;Qing Wu;Nian Fu;Yang Hu;Ting Cao)
    《中国医学科学杂志:英文版》封面
      2010年
    • 01

    主管单位:卫生部

    主办单位:中国医学科学院中国协和医科大学

    主  编:刘德培

    地  址:北京市东单三条9号中国医学科学杂志英文版

    邮政编码:100730

    电  话:010-65133074 65105897

    电子邮件:actacams@263.net.cn

    国际标准刊号:issn 1001-9294

    国内统一刊号:cn 11-2752/r

    单  价:25.00

    定  价:100.00


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