Enhanced External Counterpulsation Treatment Inhibitting Advanced Atherosclerotic Plaque Progression by Augmenting the Plaque Wall Stress: An in vivo FSI Study Based on Animal Experiment 免费阅读 下载全文 Enhance external counterpulsation(EECP) procedure has exhibited itself to be an effective therapy for the management of ischemic cardiovascular diseases.However,considering that EECP significantly increases the acute diastolic pressure,whether it will intervene in the chronic progression of advanced plaque causing great concern in clinical application,but yet remains elusive presently.In the current paper,a fluid-structure interface(FSI) numerical model of artery with plaque component was developed based on in vivo hemodynamic measurement performed in a porcine model,to calculate the mechanical stresses of the plaque before and during EECP,and in turn to assess the potential effects of long-term EECP treatment on plaque progression.The results show that EECP augmented the wall shear stress(WSS) and plaque wall stress(PWS) over the cardiac cycles,as well as the spacial oscillatory of WSS(WSSG).During EECP treatment,the PWS level respectively raised 6.82% and 6.07% in two simulation cases.The current pilot study suggests that EECP treatment may play a positive effect on inhibiting the continued plaque progression by increasing the PWS level over the cardiac cycles.Meanwhile,the plaque morphology should be taken into consideration while making patient-specific plan for long-term EECP treatment in clinic.
Intracellular Calcium Integrates Complex Signaling to Control Stem Cell Activity 免费阅读 下载全文 <正>Adult stem cells ensure continuous regeneration of tissues throughout our entire life.But the activity of these stem cells has to be carefully controlled in order to support regeneration without cancer.How this balanced control is achieved and maintained as the organism ages remains a critical question in stem cell biology.Researchers have identified a new mode of stem cell regulation.Working in the fly gut,scientists and colleagues show that stem cells adjust their proliferative activity in
Comparative Study on the Dielectric Properties Between Living and Non-living from Human and Animal Livers 免费阅读 下载全文 The data of dielectric properties of human tissues mainly comes from animal tissues or human corpse at present.Up to now,there has not been a report of dielectric properties of human living liver.This paper aims to studying the dielectric properties of human living liver and comparing the results with those of animal living liver as well as the human non-living liver.In vitro measurements of living and non-living livers from human and rabbit are shown in the range of 10 Hz to 100 MHz.Analysis of the conductivity,permittivity and characteristic parameters from the data were made.The conductivity of three kinds of liver were markedly different at low frequency: 0.06 S/m(living rabbit liver),0.13 S/m(living human liver) and 0.24 S/m(non-living human liver); The Cole parameters that best characterize the liver of human and rabbit are R0,fc1,ΔR1 and R∞; The Cole parameters that best characterize the living and non-living liver of human are R0,fc1,ΔR1,ΔR2 and R∞.In conclusion,we can’t substitute the dielectric properties of animal or human corpse liver for the living human liver.The results suggest that the study on the dielectric properties of living human tissues has great significance.
Sielectric Properties of Terahertz Windows Materials for Bio-sample Measurement 免费阅读 下载全文 We presented the dielectric properties of three materials for bio-sample measurement using THz transmission spectroscopy.The materials,PE,COC and PVDF,have sufficient transmittance.The results demonstrate that PVDF membranes are suitable media for THz transmission spectrum above 0.3 THz.However,it is not property to measure the solution sample because of the water existed after active processing by ethanol.In this paper,the refractive index,the absorption coefficient,and the complex dielectric functions in the THz region are compared for each material.From the measured dielectric properties,the loss mechanism of THz radiation for each material is also discussed.
Forward-backward Minimum Variance Beamforming Combined with Coherence Weighting Applied to Ultrasound Imaging 免费阅读 下载全文 Currently,the delay-and-sum(DAS) algorithm is used as a standard technique in ultrasound beamforming.However,the adaptive ultrasound beamformer shows its superiority over the traditional beamformer,DAS,in many ways.In this paper,we proposed a novel adaptive beamformer which combined the minimum variance(MV)adaptive beamformer together with coherence weighting factor(CF) and forward-backward averaging(FB) to medical ultrasound imaging.We called it the forward-backward averaging coherence weighting minimum variance(FB-CF-MV) beamformer.Based on Sonix RP system,we built an ultrasound beamforming research platform.We used this open platform to collect pre-beamforming RF data,and then processed them in Matlab.We tested our algorithm on a fetal ultrasound phantom and compared it with DAS and MV algorithm.The results showed that the new beamformer improved image contrast,making the image outline smoother while compared with other two algorithms.
Punchy Proteins Could Help Advance Drug Delivery 免费阅读 下载全文 <正>Earth’s critters have developed countless ways to survive.Some bacteria that live inside paramecia,which are tiny aquatic organisms,use a coiled protein ribbon that unfurls like a Chinese paper yo-yo to deliver a toxin to threatening organisms.The protein packs a punch,bursting through membranes of the paramecia’s competitors as it elongates.Now,scientists report that the protein could someday deliver drugs or become integrated into tiny devices.
Temperature Control System for Cell Continuous Observation under the Microscope 免费阅读 下载全文 This paper developes a temperature control system in order to carry out a real time and continuous observation on living cells under the microscope.In this system,transparent indium tin oxid(ITO) conductive film was used as a heater,temperature was measured by the temperature dependence of resistance behavior of the ITO film,C8051F340 single-clup was used as the control hardware core,and the modified PID algorithm and pulse width modulation(PWM) were adopted as the key control software programs.The temperature system had a simple structure without added temperature sensor,an uniform temperature distribution within ±1℃ on the ITO film surface and temperature control precision of ±0.2℃ could be obtained.The system could maintain a good growth state for BHK-21 living cell under the microscope for 48 h.
Cells from Cow Knee Joints Used to Grow New Cartilage Tissue in Laboratory 免费阅读 下载全文 <正>In an effort to develop a method for cartilage tissue engineering,researchers successfully used cartilage cells from cow knee joints.By creating a successful method with conditions conducive to growing healthy cartilage tissue,the findings could help lead to a new treatment cure for osteoarthritis using stem cell-based tissue engineering.Articular cartilage is tissue that is found on all the joint surfaces in the body.Since the tissue is
Quantitative Evaluation of Bioluminescence Imaging Based on Radiative Transfer Equation 免费阅读 下载全文 Bioluminescence imaging is a kind of emerging detection technology at cellular,molecular and genetic level.The most popular bioluminescence imaging model is diffusion approximation(DA).However,because of the ill-posedness of the DA-based inverse problem and the instability of reconstruction algorithms,the location accuracy of the reconstructed sources is low.Radiative transfer equation(RTE),which considers the direction of the photon migration and the effect of absorption and scattering in tissues,can accurately express the transmission of bioluminescent photons through the tissues.In this paper,we studied the bioluminescence imaging based on the RTE.2D simulations were performed,and quantitative evaluation was given by the absolute source position error,the relative source area error and the minimum bounding box.The results of the experiment showed that the imaging quality based on RTE was better than that one based on DA.
《中国生物医学工程学报》(英文版)稿约 免费阅读 下载全文 <正>《中国生物医学工程学报》是经国家科技局批准出版,中国生物医学工程学会主办的英文版学术期刊。刊物贯彻'百花齐放,百家争鸣'的方针和理论与实践相结合的方针,报道我国生物医学工程学科的最新进展,是我国生物医学工程学与相关临床医学工作者进行学术交流的园地。1.征稿范围本刊刊登有关生物力学、生物信息、生物材料、人工器官、生物控制、生物医学测定和有关生物医学工程的文章。2.来稿要求和注意事项★来稿请附第一作者简介,包括:作者姓名、出生年月、工作单位、从事专业、职称(学位)、通信地址、联系电话、电子邮箱。