Safety and outcomes of cochlear implantation in the elderly:A review of recent literature Global demographic changes related to longevity are leading to increasing numbers of the elderly,for whom hearing loss is a significant cause of morbidity and disability.Once met with reticence,severely hearing impaired older adults are increasingly being considered for cochlear implantation(CI).Significant data indicate that CI in the elderly population is safe,well-tolerated,and effective.Risks from CI surgery and anesthesia are low and generally comparable to rates in other age groups.Outcomes studies regarding CI in older adults have shown excellent improvements to speech perception,quality of life,and even cognition.Overall,currently available data suggests that advanced age should not,in itself,be considered a barrier to implantation.This review paper will highlight selected articles from recent medical literature regarding the safety and efficacy of CI in the elderly population.
Aims&Scope <正>Journal of Otology is a peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear.This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with
Anti-apoptotic treatment in mouse models of age-related hearing loss Age-related hearing loss(AHL),or presbycusis,is the most common neurodegenerative disorder and top communication deficit of the aged population.Genetic predisposition is one of the major factors in the development of AHL.Generally,AHL is associated with an age-dependent loss of sensory hair cells,spiral ganglion neurons and stria vascularis cells in the inner ear.Although the mechanisms leading to genetic hearing loss are not completely understood,caspase-family proteases function as important signals in the inner ear pathology.It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL.Here,we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.
Arsenic ototoxicity High levels of arsenic are found in many parts of the world and more than 100 million people may have been exposed to it.There is growing evidence to indicate that arsenic has a deleterious effect on the auditory system.This paper provides the general information of arsenic and its ototoxic effects.
A comparison of effects of systemic and intratympanic steroid therapies for sudden sensorineural hearing loss:A meta-analysis Objective:To evaluate the efficacy and safety of intratympanic and systemic steroid therapies in the initial treatment of Sudden Sensorineural Hearing Loss(SSNHL) patients.Methods:A comprehensive search of PubMed,Wanfang database and CNKI(China National Knowledge Infrastructure) was performed covering the period from January 1990 to July 2014.A meta-analysis was conducted after filtering by the criteria of Cochrane Collaboration.Three hundred fifty six subjects in nine studies allocated to the group of intratympanic steroid therapies and 343 controls receiving systemic steroid therapies met the criteria for meta-analysis.The data were extracted and analyzed using the Rev Man 5.3 meta-analysis software.Results:The total effectiveness rate in SSNHL patients receiving intratympanic steroid therapies did not differ statistically from patients receiving systemic therapies(RR = 1.08,95%CI = 0.99-1.99,P = 0.10),although the rate of full hearing recovery in this group differed significantly from patients receiving systemic therapies(RR = 1.29,95%CI = 1.00-1.66,P = 0.05).Conclusion:Local steroid therapy appears to generate higher rate of complete hearing recovery than systemic steroid treatment as an initial treatment for SSNHL,which may be especially useful for patients in whom systemic steroids are contraindicated.
New language outcome measures for Mandarin speaking children with hearing loss Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM) was carefully designed to be a comprehensive standardized Mandarin assessment normed in Mainland China.Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM)was carefully designed to be a comprehensive standardized Mandarin assessment normed in Mainland China.Results:This paper summarizes the evidence-based item design process and validity and reliability results of DREAM.A pilot study reported here shows that DREAM provided detailed information about hearing impaired children’s language abilities and can be used to aid intervention planning to maximize progress.Conclusion:DREAM represents an example of translational science,transferring methods from empirical studies of language acquisition in research environments into applied domains such as assessment and intervention.Research on outcomes in China will advance significantly with the availability of evidence-based comprehensive language tests that measure a sufficient age range of skills,are normed on Mandarin speaking children in mainland China,and are designed to capture features central to Mandarin language acquisition.
Climatic variations and benign paroxysmal positional vertigo Benign paroxysmal positional vertigo(BPPV) is probably the most common diagnosis at vertigo clinics.Seasonal cycles of several human illnesses could be attributed variously to changes in atmospheric or weather conditions.In this retrospective study,patients with BPPV from January 2010 to December 2012 were studied,and their charts were reviewed.Statistical analysis revealed a statistically significant difference in patients’ numbers among different months of the year.Also there is a significant statistical correlation between the numbers of patients with climatic variations especially the temperature.The present paper discusses the possible explanations for these results which confirms the seasonal variations in BPPV,together with a review of literature to view the possible associations with other disorders that causes such seasonality.
Communication outcomes following cochlear implantation in a child with cystic cochleovestibular anomaly Cochlear implantation is one of the best amongst the various management options available for children and adults with severe to profound sensorineural hearing loss.Inner ear and internal auditory canal(IAC) malformations accounts to approximately 25% of congenital sensorineural hearing loss in children.The primary goal of this report was to evaluate the communication outcomes after cochlear implantation in a child with cystic cochleovestibular anomaly(CCVA).The child was evaluated through various standardized outcome measures at regular intervals to track the progress in terms of auditory and spoken language skills.The scores on Categories of Auditory Perception(CAP),Meaningful Auditory Integration Scale(MAIS),Speech Intelligibility Rating(SIR),Meaningful Use of Speech Scale(MUSS),and listening and spoken language skills showed a significant leap in 12 months duration post implantation.The report thus highlights and correlates the significant progress in auditory and spoken language skills of the child with congenital malformations to appropriate auditory rehabilitation and intensive parental training.
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