现代医院管理中危机评估是医院危机管理的一个重要环节，它对制定新一轮的危机预防措施有着重要的作用。运用根本原因分析（root cause analysis，RCA）及失效模型分析（failure mode and effects analysis，FMEA）相结合的方法进行危机评估已经在国际上得到认可。在中国的医院管理行业，应结合中国现状，进一步完善推广RCA和FMEA的使用，使中国的医院管理更加有效。
The Time Course of D1 Agonist Induced Striatonigral ERK1/2 Signaling in a Rat Model of Parkinson＇ s Disease
Using a rat model of hemiparkinsonism, we examined the time-course of D1 agonist, SKF-38393-induced changes in extracellular signaling regulated kinases 1/2 （ERK1/2） phosphorylation in the striatum and substantia nigra （SN）. We unilaterally lesioned the rat median forebrain bundle with 6-hydroxydopamine. Dopaminergic lesioned rats were administered with SKF-38393 and perfused at 15, 30, 60, or 120 minutes after the drug. Immunohistochemical analysis of striatum and SN revealed, as expected, a loss of tyrosine hydroxylase and a decrease of substance P in lesioned rats. SKF-38393 induced a robust increase in phospho-ERK1/2 levels in the le-sioned striatum, which peaked at 15 min and substantially declined by 120 min. We report for the first time that similar changes were observed in the SN. The time-dependent ERK 1/2 activation in the striatonigral neurons may play a role in the therapeutic and/or side effects such as dyskinesias related to the dopamine agonist treatment for Parkinson＇ s disease.